Cohort Studyhigh evidence
US overdose mortality saw first drop below the Jalal-Burke exponential growth curve in 2024.
The International journal on drug policy·July 1, 2026·PMID 42107255
Why it mattersFor the first time in decades, US overdose deaths have meaningfully deviated below the long-standing exponential trend, signaling a potential shift in the overdose crisis trajectory. This warrants attention from pain and emergency medicine specialists who manage substance use sequelae.
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