Randomized Trialhigh evidence
Liposomal bupivacaine versus ropivacaine for surgical site infiltration in lumbar fusion: a prospective randomized controlled trial.
Annals of medicine·December 1, 2026·PMID 42504098
Why it mattersEffective multimodal analgesia after lumbar fusion remains a challenge, and excessive opioid use is linked to adverse outcomes. This trial provides direct comparative evidence that a liposomal bupivacaine–based infiltration regimen can meaningfully reduce opioid requirements and pain burden in the early postoperative period without compromising safety or recovery.
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