Randomized Trialhigh evidence

Constant-routine protocol reveals an endogenous circadian rhythm in diet-induced thermogenesis with a peak in the biological morning.

Metabolism: clinical and experimental·May 25, 2026·PMID 42190872

Why it matters

It provides mechanistic evidence that the body's internal clock influences how we process calories, potentially explaining why late eating is linked to weight gain. This moves beyond association to demonstrate a direct circadian effect on metabolism.

Infographic summary of Constant-routine protocol reveals an endogenous circadian rhythm in diet-induced thermogenesis with a peak in the biological morning.
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