Randomized Trialhigh evidence
Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial.
Nature medicine·January 1, 2026·PMID 41214345
Why it mattersMany patients with chest pain and unobstructed coronary arteries lack a clear diagnosis and effective treatment. This trial provides randomized evidence that stress MRI-based endotyping can identify coronary microvascular dysfunction, guide therapy, and substantially improve symptoms and quality of life.
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