Randomized Trialhigh evidence
Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.
Aging cell·August 1, 2025·PMID 40459998
Why it mattersWerner syndrome is a rare progeroid disorder with premature atherosclerosis, skin ulcers, and renal decline. This trial provides the first controlled evidence that NAD+ repletion with NR may mitigate these complications, offering a potential therapeutic strategy for this high-risk population.
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