Basic Sciencemoderate evidence
Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model.
Science translational medicine·February 19, 2025·PMID 39970235
Why it mattersScarring after skin injury remains a major clinical challenge with limited therapeutic options. This large-animal study provides strong preclinical evidence that a single local dose of a YAP inhibitor can redirect healing toward regeneration, offering a translatable strategy to reduce fibrosis and improve functional and cosmetic outcomes.
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