Randomized Trialhigh evidence
Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial.
The American journal of sports medicine·November 1, 2025·PMID 41105117
Why it mattersPostoperative shoulder stiffness is a common complication after rotator cuff repair, prolonging recovery and impairing function. This trial provides high-level evidence that a safe, inexpensive, and widely available medication can reduce this complication, offering a potential prophylactic strategy for pain specialists and orthopedic surgeons.
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