Randomized Trialhigh evidence
Does Metformin Interfere with Cardiorespiratory and Substrate Oxidation Adaptations to Exercise Training in Metabolic Syndrome Patients? A Randomized Placebo-Controlled Trial.
Biomolecules·July 1, 2026·PMID 42509765
Why it mattersMetformin and exercise are commonly co-prescribed for metabolic syndrome, yet their interaction on fitness and fat metabolism adaptations is unclear. This trial reveals a dissociated response: metformin may enhance lipid oxidation while slightly attenuating cardiorespiratory gains, especially in older patients, informing personalized exercise and medication strategies.
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