Meta-Analysishigh evidence
GLP-1 Receptor Agonists in Heart Failure: A Systematic Review and Meta-analysis with Phenotype-Specific Effects and Dual Analytical Frameworks.
Drugs·September 26, 2026·PMID 42791433
Why it mattersHeart failure with preserved ejection fraction has limited effective therapies, and many patients have obesity. These findings suggest GLP-1 RAs may offer meaningful cardiovascular and HF event reduction in this phenotype, informing treatment selection and guideline discussions.
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