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Engineering Spatially Organized Hair Peg-like Structures in Human Skin Constructs Using Keratinocyte-Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds.
Acta biomaterialia·July 25, 2026·PMID 42501773
Why it mattersCurrent tissue-engineered skin substitutes lack hair follicles, limiting functional and aesthetic outcomes. This platform addresses the rapid loss of hair-inductive capacity in cultured dermal papilla cells and the challenge of spatially organizing follicular structures, providing a scalable method to incorporate early-stage follicular units into engineered skin using adult human cells.
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