Cohort Studyhigh evidence
Impact of Sleep Apnea on Perivascular Diffusivity and Cognition: A 4-Year Prospective Cohort Study.
American journal of respiratory and critical care medicine·December 1, 2025·PMID 40788707
Why it mattersOSA is a common and treatable condition linked to cognitive decline, but the mechanisms remain unclear. This study provides longitudinal evidence that impaired perivascular fluid dynamics, measured by DTI-ALPS, may be a key pathway through which OSA affects memory, offering a potential biomarker for monitoring brain health in patients with sleep-disordered breathing.
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