Meta-Analysisvery high evidence
A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.
Nature medicine·July 1, 2026·PMID 42387214
Why it mattersClinicians often assume that longer antihypertensive treatment yields greater relative risk reduction. This analysis clarifies that the proportional benefit is established within months and does not grow over time, reinforcing the importance of early intervention and prioritizing higher-risk patients rather than relying on prolonged treatment in low-risk individuals.
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