Randomized Trialhigh evidence
Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial.
The Lancet. Respiratory medicine·May 1, 2026·PMID 41881047
Why it mattersThis large, pragmatic trial suggests that adding procalcitonin to standard sepsis assessment may improve survival without increasing antibiotic use, challenging assumptions about biomarker-guided care in the emergency department.
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