Randomized Trialhigh evidence
Craving and personal functioning as mediators of extended-release buprenorphine efficacy: A four-way decomposition analysis from a randomised trial.
Addiction (Abingdon, England)·July 1, 2026·PMID 42384966
Why it mattersUnderstanding mediators of BUP-XR efficacy can help clinicians target treatment mechanisms. The finding that reduced need-related craving partially explains benefit supports focusing on craving as a therapeutic target and monitoring tool in OUD pharmacotherapy.
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