Meta-Analysishigh evidence
Left Atrial Appendage Closure vs Anticoagulation for Stroke Prevention in Atrial Fibrillation: Meta-Analysis of Randomized Trials.
JACC. Clinical electrophysiology·July 6, 2026·PMID 42501028
Why it mattersFor cardiologists managing atrial fibrillation patients, this analysis provides contemporary randomized evidence that LAAC offers comparable stroke prevention to OAC while substantially lowering long-term bleeding risk, supporting its role in patients with high bleeding risk or contraindications to anticoagulation.
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