Systematic Reviewhigh evidence
Long-term hormone therapy for perimenopausal and postmenopausal women.
The Cochrane database of systematic reviews·September 4, 2026·PMID 42695385
Why it mattersHormone therapy decisions require balancing menopausal symptom relief against long-term risks, and this review provides the most current pooled evidence on outcomes like cancer, cardiovascular events, and fractures. The findings help clinicians counsel patients on risk profiles that differ by HT formulation and hysterectomy status.
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