Randomized Trialhigh evidence
Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery: A Randomized Clinical Trial.
JAMA·August 12, 2026·PMID 42584898
Why it mattersAnesthesiologists often choose between TIVA and inhalational agents based on patient factors and institutional practice, but comparative effectiveness data on patient-centered outcomes have been limited. This large trial provides robust evidence that both techniques yield equivalent recovery and safety in older surgical patients, allowing clinicians to prioritize other considerations such as cost, availability, and individual patient risk factors.
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