Randomized Trialhigh evidence
The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial.
Journal of the American Nutrition Association·January 1, 2026·PMID 40854087
Why it mattersMenopause-related cognitive and metabolic changes lack targeted nutritional interventions. This trial provides early evidence that a moderate-dose, highly soluble creatine formulation may improve reaction time, brain creatine, and lipid profiles in this population, offering a potential low-risk adjunct for cognitive and metabolic health during the menopausal transition.
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