Cohort Studymoderate evidence
Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21.
BMJ (Clinical research ed.)·August 25, 2026·PMID 42642105
Why it mattersCTE is a major concern for former NFL players, but prevalence estimates have been limited by brain donation bias. This study provides a range of possible CTE prevalence at death, helping clinicians understand the burden of neuropathology in this population and its link to dementia.

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