Cohort Studymoderate evidence

Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21.

BMJ (Clinical research ed.)·August 25, 2026·PMID 42642105

Why it matters

CTE is a major concern for former NFL players, but prevalence estimates have been limited by brain donation bias. This study provides a range of possible CTE prevalence at death, helping clinicians understand the burden of neuropathology in this population and its link to dementia.

Infographic summary of Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21.
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