Randomized Trialhigh evidence

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial.

JAMA·August 5, 2026·PMID 42554995

Why it matters

Optimal duration of therapeutic hypothermia after cardiac arrest has been uncertain, with practice varying widely. This large, rigorous trial provides strong evidence that prolonging cooling beyond 6 hours does not improve neurological recovery, potentially simplifying post-arrest care and reducing resource utilization.

Infographic summary of Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial.
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