Randomized Trialhigh evidence

Interindividual variability in gut microbiome mediates the efficacy of resistant starch on MASLD.

Cell metabolism·December 2, 2025·PMID 41270737

Why it matters

It explains why some patients with MASLD do not respond to resistant starch, identifies a microbial mechanism, and offers a tool to personalize prebiotic therapy, which could improve treatment selection and outcomes in metabolic liver disease.

Infographic summary of Interindividual variability in gut microbiome mediates the efficacy of resistant starch on MASLD.
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