Cohort Studymoderate evidence
A functional connectome identifies vulnerability to cognitive decline and Alzheimer's disease progression.
Science advances·November 6, 2026·PMID 42981415
Why it mattersEarly identification of individuals at risk for Alzheimer's disease is critical for prevention and intervention. This connectomic biomarker offers a non-invasive, imaging-based method to stratify cognitively normal older adults into resilience and vulnerability subtypes, potentially enabling earlier risk assessment and targeted monitoring.
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