Randomized Trialhigh evidence
Metformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial.
Mechanisms of ageing and development·September 3, 2026·PMID 42692117
Why it mattersAsian Indians have high rates of prediabetes progression and accelerated biological aging. This trial provides randomized evidence that metformin may influence cellular aging markers beyond glucose control, relevant for clinicians managing metabolic risk and interested in longevity interventions.
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