Cohort Studyhigh evidence
Prenatal exposure to buprenorphine or methadone and adverse neurodevelopmental outcomes: population based cohort study.
BMJ (Clinical research ed.)·April 15, 2026·PMID 41985931
Why it mattersFor clinicians managing opioid use disorder in pregnancy, this study supports buprenorphine as a reasonable option when neurodevelopmental safety is a concern. It helps frame counseling by suggesting buprenorphine is not associated with worse long-term child neurodevelopment than methadone.
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