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Ketamine Infusion and Risk of Postoperative Nausea and Vomiting and Adverse Outcomes in Surgical Patients: A Secondary Analysis of the IMPAKT Randomized Trial.

Anesthesia and analgesia·June 29, 2026·PMID 42372120

Why it matters

Ketamine is widely used for multimodal analgesia, but concerns about PONV may limit its use. This analysis provides reassurance that ketamine infusion does not elevate PONV risk, supporting its role in opioid-sparing strategies.

Infographic summary of Ketamine Infusion and Risk of Postoperative Nausea and Vomiting and Adverse Outcomes in Surgical Patients: A Secondary Analysis of the IMPAKT Randomized Trial.
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