Randomized Trialhigh evidence

Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicentre, phase 2b, randomised, placebo-controlled trial.

Lancet (London, England)·June 20, 2026·PMID 42259343

Why it matters

Elecoglipron is an oral small-molecule GLP-1 agonist without food or fluid restrictions, potentially offering a convenient alternative to injectable or peptide-based oral GLP-1 therapies for metabolic disease.

Infographic summary of Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicentre, phase 2b, randomised, placebo-controlled trial.
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