Cohort Studylow evidence
Skeletal muscle is a critical site of disrupted lipid metabolism in male hypogonadism: an in vivo interventional study.
The Journal of clinical endocrinology and metabolism·October 22, 2026·PMID 42908258
Why it mattersHypogonadism is linked to adverse cardiometabolic outcomes, but tissue-specific mechanisms are unclear. This study shows that plasma metabolomics alone misses critical changes in skeletal muscle, where androgens regulate lipid partitioning. Understanding these tissue-specific effects may clarify how testosterone influences metabolic risk and muscle health.
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