Post-Transfusion Management of RhD-Negative Females of Childbearing Potential Who Receive RhD-Positive Low-Titer Group O Whole Blood and Red Blood Cells During Trauma Resuscitation: A Joint Position Statement and Resource Document of the American College of Surgeons Committee on Trauma (ACS-COT), Prehospital Blood Transfusion Coalition (PBTC), National Association of Emergency Medical Services Physicians (NAEMSP), Trauma Hemostasis and Oxygenation Research (THOR) Network, and Allo Hope Foundation (AHF).

Journal of the American College of Surgeons·July 22, 2026·PMID 42490058

Why it matters

Trauma systems increasingly use low-titer group O whole blood, yet RhD-negative females of childbearing potential are 40% less likely to receive it than males, raising equity concerns. This guidance helps emergency and critical care clinicians balance immediate survival against future reproductive risks and standardize post-transfusion management to mitigate alloimmunization.