Randomized Trialhigh evidence
Clinical Pathway Management for Platelet-Rich Plasma Therapy in Kellgren-Lawrence Grade I and II Knee Osteoarthritis: A Prospective, Multicenter, Double-Blind Randomized Controlled Trial.
The American journal of sports medicine·October 26, 2026·PMID 42929654
Why it mattersPRP outcomes for knee osteoarthritis vary widely, and many trials show no benefit. This study suggests that standardizing the entire treatment process—not just the injection—may improve pain and function while reducing adverse events, offering a practical framework for clinicians who use PRP.
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