Case-Controlmoderate evidence

Gut Microbiome in Depression with and without REM Sleep Behavior Disorder.

Molecular psychiatry·July 23, 2026·PMID 42493609

Why it matters

MDD with comorbid RBD may represent a distinct subtype with underlying α-synucleinopathy risk, and gut microbiome signatures could aid in stratifying psychiatric patients for neurodegenerative vulnerability.

Infographic summary of Gut Microbiome in Depression with and without REM Sleep Behavior Disorder.
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