Basic Sciencelow evidence
Mechanical Distraction Engages a Neuro-Immune Program to Drive Regenerative Soft-Tissue Healing in Ilizarov Bone Transport.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)·October 25, 2026·PMID 42928501
Why it mattersIlizarov bone transport is clinically used to regenerate bone and soft tissue, but the biological basis for its soft-tissue benefits has been unclear. This study provides a mechanistic framework linking mechanical distraction to sensory neuro-immune signaling, which could inform adjunctive therapies or optimization of distraction protocols in orthopedic and regenerative medicine.
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