Randomized Trialhigh evidence
Intraoperative Dobutamine Plus Norepinephrine to Prevent Postoperative Acute Kidney Injury in Septic Shock: A Randomized Clinical Trial.
JAMA·October 14, 2026·PMID 42872914
Why it mattersSeptic shock with persistent hypoperfusion often leads to postoperative AKI, and current dobutamine recommendations rest on very low-certainty evidence. This trial provides randomized data that adding dobutamine intraoperatively may protect renal function in a high-risk surgical population.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled