Randomized Trialhigh evidence

Noninferiority of One HPV Vaccine Dose to Two Doses.

The New England journal of medicine·December 18, 2025·PMID 41337735

Why it matters

A single-dose HPV schedule could dramatically simplify vaccination programs, reduce costs, and improve global coverage, especially in low-resource settings where multidose regimens are a barrier.

Infographic summary of Noninferiority of One HPV Vaccine Dose to Two Doses.
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