Randomized Trialhigh evidence
Intensive diet or knee arthroplasty for severe knee osteoarthritis: The inka randomised trial.
Osteoarthritis and cartilage·July 10, 2026·PMID 42431586
Why it mattersFor patients with severe knee osteoarthritis and obesity who are surgical candidates, a structured weight loss program alone does not provide comparable symptom relief to knee arthroplasty, despite meaningful weight reduction. This informs shared decision-making when patients consider non-surgical alternatives.
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