Randomized Trialhigh evidence
Efficacy of systemic lidocaine versus ultrasound-guided adductor canal block for patients undergoing total knee arthroplasty: a randomized, double-blinded, non-inferiority study.
Regional anesthesia and pain medicine·July 28, 2026·PMID 42521407
Why it mattersWhen regional anesthesia is not feasible for total knee arthroplasty, intravenous lidocaine offers a practical, non-inferior analgesic alternative to adductor canal block for 24-hour opioid consumption, though early PACU pain control may be slightly less effective.
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