Randomized Trialhigh evidence
Caloric restriction improves glycemic control via the adiponectin-ceramide axis in non-obese men and women: the CALERIE™ 2 randomized controlled trial.
Nature communications·July 9, 2026·PMID 42425963
Why it mattersIt identifies a plausible adiponectin-ceramide axis through which caloric restriction may improve glycemic control, offering mechanistic insight relevant to longevity and metabolic health interventions.
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