Randomized Trialhigh evidence
Topical Airway Anesthesia for Tracheal Intubation Prevents Intraoperative Hypotension and Improves Outcomes in Severe Traumatic Brain Injury by Reducing Anesthesia Induction: A Single-Center, Single-Blinded, Randomized Trial.
Journal of patient safety·July 20, 2026·PMID 42474272
Why it mattersIntraoperative hypotension during anesthesia induction worsens outcomes in severe TBI. This trial suggests that avoiding standard induction agents via topical airway anesthesia may preserve hemodynamics and improve survival and neurological recovery, offering a potential strategy for neuroanesthesia management.
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