Cohort Studyhigh evidence
Plasma proteomic signature of frailty in 50,506 adults.
Cell metabolism·May 5, 2026·PMID 41844148
Why it mattersThis study suggests frailty has a measurable plasma proteomic signature that may function as a biomarker of biological aging and multisystem risk. For clinicians interested in aging, it is a strong signal that frailty biology extends beyond phenotype-based assessment, though translation to bedside care is not yet established.
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