Randomized Trialhigh evidence
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.
Experimental gerontology·June 1, 2026·PMID 41941966
Why it mattersThis study provides evidence that combining high-velocity resistance training with creatine can enhance multiple domains of healthy aging, including neuroprotection and physical function. It highlights modality-specific effects, helping clinicians tailor exercise prescriptions for older adults.
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