Basic Sciencemoderate evidence
Spermidine is essential for fasting-mediated autophagy and longevity.
Nature cell biology·September 1, 2024·PMID 39117797
Why it mattersIt identifies spermidine as a key mediator of fasting's benefits, suggesting that polyamine metabolism could be a target for interventions that mimic caloric restriction, relevant for longevity and age-related disease prevention.
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