Randomized Trialhigh evidence
Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty: A Randomized Controlled Trial.
Anesthesiology·January 1, 2026·PMID 41086424
Why it mattersPostoperative delirium is a common and serious complication in elderly arthroplasty patients, and this trial suggests S-ketamine may offer a protective effect when used in a neuraxial anesthesia setting, potentially improving perioperative outcomes.

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