Randomized Trialhigh evidence
A Combined Intravenous and Oral Metoprolol Regimen to Reduce Perioperative Myocardial Injury: The ORION Trial.
Anesthesia and analgesia·May 1, 2026·PMID 41105735
Why it mattersPerioperative myocardial injury is a significant complication in noncardiac surgery, and beta-blockers are commonly used for cardioprotection. This trial may provide evidence on an optimized dosing strategy to improve outcomes.
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