Randomized Trialhigh evidence
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury: The BICARICU-2 Randomized Clinical Trial.
JAMA·December 9, 2025·PMID 41159812
Why it mattersThis large RCT clarifies that sodium bicarbonate does not improve survival in severe acidemia with acute kidney injury, but it may reduce the need for dialysis—a finding relevant to ICU decision-making.
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