Randomized Trialhigh evidence
Large increases in resistance training volume do not impair muscle hypertrophy or anabolic-catabolic molecular signaling in trained individuals.
Journal of applied physiology (Bethesda, Md. : 1985)·July 16, 2026·PMID 42461790
Why it mattersClinicians and coaches often worry that large training volume jumps may overtax recovery and blunt muscle growth. This study provides direct evidence that in trained individuals, a +120% volume increase does not compromise hypertrophy or key molecular pathways, supporting more flexible volume prescription.
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