Randomized Trialhigh evidence
Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation.
The New England journal of medicine·April 25, 2026·PMID 42041224
Why it mattersCurrent guidelines recommend a trial of antiarrhythmic drugs before ablation for persistent AF. This trial provides high-level evidence that first-line PFA may offer superior rhythm control, potentially shifting the initial treatment paradigm.
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