Randomized Trialhigh evidence
CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial.
EBioMedicine·July 1, 2026·PMID 42315445
Why it mattersIt demonstrates that high-dose DHA can reach the CNS in this at-risk population, but the lack of cognitive or structural benefit over 2 years challenges the rationale for DHA supplementation as a standalone preventive strategy, informing clinical counseling and future trial design.
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