Basic Sciencemoderate evidence
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell stem cell·May 1, 2025·PMID 40118065
Why it mattersSkeletal repair and aging-related bone loss are major clinical challenges in orthopedics and regenerative medicine. This work reveals that skeletal stem cell diversity is site-specific and that age-related dysfunction stems from a shift toward fibrogenic rather than osteogenic cells, offering a cellular target for therapeutic intervention.
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