Studymoderate evidence
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics.
Nature neuroscience·December 1, 2025·PMID 41162627
Why it mattersSleep deprivation impairs attention through a coordinated neurovascular and fluid dynamic mechanism, not just isolated neural fatigue. This coupling of CSF flow, pupil changes, and attentional lapses offers a physiological basis for cognitive fluctuations that may inform monitoring or intervention strategies in settings where sustained attention is critical.
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