Basic Sciencelow evidence
Donor-intrinsic regenerative potential outweighs histocompatibility in iPSC-derived skeletal muscle engraftment in nonhuman primates.
Stem cell reports·October 15, 2026·PMID 42880242
Why it mattersFor regenerative medicine, the finding that donor-intrinsic regenerative potential can override histocompatibility barriers under immunosuppression supports the feasibility of off-the-shelf allogeneic iPSC-based therapies for muscular dystrophies, potentially simplifying donor selection and expanding patient access.
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