Meta-Analysishigh evidence
Influence of platelet count on the clinical effectiveness of platelet-rich plasma in the treatment of knee osteoarthritis: A systematic review and meta-analysis.
Orthopaedics & traumatology, surgery & research : OTSR·October 9, 2025·PMID 41067625
Why it mattersPRP preparation is highly variable, and optimal platelet dosing is unknown. This analysis provides evidence that moderate platelet enrichment (2–4×) may be sufficient, potentially guiding standardization and reducing unnecessary processing complexity.
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